Hydroxypropyl beta cyclodextrin (injection grade) CAS: 128446-35-5

  Deli & reg; Hydroxypropyl beta cyclodextrin (HP - & beta; - CD) is a hydroxyalkylated derivative of beta cyclodextrin (& beta; - CD)
Hydroxypropyl beta cyclodextrin is non-toxic and has no side effects
Due to its special structure, it can greatly improve the solubility of insoluble drugs and make insoluble or insoluble drugs soluble in water
Therefore, it can effectively improve the bioavailability of drugs, greatly improve the quality and dosage forms of drugs, and is widely used in the development and production of new drugs

The introduction of hydroxypropyl breaks the intramolecular cyclic hydrogen bond of beta cyclodextrin, and overcomes the main disadvantage of poor water solubility of beta cyclodextrin while maintaining the cavity of cyclodextrin
It is one of the cyclodextrin derivatives which have been studied deeply and applied widely at present
It is mainly used in food, medicine and cosmetics industries

1
In the pharmaceutical industry, hydroxypropyl beta cyclodextrin is an ideal injection solubilizer and drug excipient because of its low relative surface activity and hemolytic activity and no irritation to muscle
It can improve the water solubility of insoluble drugs, increase drug stability, improve drug bioavailability, increase the curative effect or reduce the dosage of drugs, adjust or control the release speed of drugs and reduce the toxic and side effects of drugs
It can be used for oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc
), transdermal absorption drug delivery systems, carriers of lipophilic targeted drugs, as well as protective agents and stabilizers of proteins

2
In the field of food and spices: hydroxypropyl beta cyclodextrin can improve the stability and long-term effect of nutritional molecules, cover up or correct the bad smell and taste of food nutritional molecules, and improve the production process and product quality
The product has good solubility in water, with a degree of substitution of 4 or above
It can be miscible with water in any proportion, and can also be dissolved in 50% ethanol and methanol

3
In the field of cosmetic raw materials: hydroxypropyl beta cyclodextrin is used as stabilizer, emulsifier and deodorant, which can reduce the irritation of organic molecules in cosmetics to skin and mucous membrane, enhance the stability of active ingredients and prevent the volatilization and oxidation of nutrients
It has certain relative hygroscopicity